Nothing.
OK, maybe not exactly nothing. I know what works for me with my somewhat unorthodox requirements, but if you want in-depth information on this topic, particularly with regards to Chicago-style amplified blues harp, instead of asking my opinion you'd be better off checking out these fine sites:
The New JT30 Page - Amplified Blues Harmonica
Harmonica Masterclass Harmonica Microphone Museum
Harp On! Harmonica Amplified
HarpAmps.com
Using low-power tube amps for blues harp
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